The provincial government media office in a statement said the militants were killed in Nazian and Lalpur districts.
The statement further added that seven Pakistani militants and fifteen ISIS loyalists were killed in total during the operations.
The Afghan Special Forces conducted an operation in Bila area of Lalpur district late on Friday night that left at least seven Pakistani militants dead.
According to the provincial government, the Afghan forces also confiscated nine assault rifles during the operation.
The US forces also conducted an airstrike in Spinzhai area of Nazian district on Friday that left fifteen ISIS militants dead, the statement added.
The provincial government says two hideouts of the terror group were also destroyed but the local residents did not suffer any casualties.
The anti-government armed militant groups have not commented regarding the report so far.
Both the Taliban and ISIS militants attempt to expand their foothold in the key and remote districts of Nangarhar province.
The movements have forced the Afghan forces ad US forces based in Afghanistan to conduct regular operations and airstrikes to eliminate the terrorists from expanding their insurgency in this province. -KP